H2N2V1, Main, Exploration, bibRecord, 002931

The search for the ideal influenza vaccine.

Identifieur interne : 002931 ( Main/Exploration ); précédent : 002930; suivant : 002932

The search for the ideal influenza vaccine.

Auteurs : F. M. Davenport

Source :

Postgraduate Medical Journal [ 0032-5473 ] ; 1979-02.

RBID : ISTEX:9F15CF1112A685FD65DC04D7EE3F9308178C0D1F

English descriptors

Teeft :
- Active immunization, Active virus, Adjuvant influenza vaccines, Allantoic, Allantoic fluid, Allantoic fluids, American journal, Andrewes, Antibody, Antibody levels, Antibody response, Antigen mass, Antigenic, Antigenic differences, Antigenic drift, Antigenic experience, Antigenic variation, Attack rate, Australian journal, Basic immunity, British journal, Burnet, Chick, Chick embryo, Clinical investigation, Culture virus, Davenport, Different ages, Dos, Environmental health, Epidemic influenza, Epidemic influenza virus, Epidemic influenza virus infection, Experimental biology, Experimental medicine, Experimental pathology, Field trial, Field trials, Filterable virus, Hennessy, Hirst, Human beings, Human influenza, Human influenza virus, Human population, Human sera, Human strains, Human subjects, Humoral factors, Ideal influenza vaccine, Ideal vaccine, Immunization, Infectious diseases, Influenza, Influenza vaccines, Influenza virus, Influenza virus vaccines, Influenza viruses, Laidlaw, Letchworth village, Magill, Mass production, Medical journal, Medical research council, Medical science, Mill hill, Monovalent vaccine, Mouse lung suspensions, Nasal, Nasal histology, Nasal lesion, Nasal secretions, Natural infection, Neutralizing antibodies, Optimal dose, Pandemic, Physiochemical injury, Pneumococcus pneumonia, Polyvalent vaccines, Possible explanation, Protective effect, Public health reports, Publishing sciences group, Respiratory epithelium, Rickettsial infections, Serum antibody, Strain composition, Subcutaneous, Subcutaneously, Surface antigens, Swine, Swine influenza, Swine virus, Vaccination, Vaccine, Vaccine effectiveness, Vaccine reactions, Viral, Virus, Virus vaccines, Volunteer studies, World health organization.

Abstract

The history of the development of influenza virus vaccine is traced from its origin with experimental studies of influenza virus in ferrets and mice and the first trials in man. Knowledge of the basis of immunity to the viruses in experimental animals and in man has grown steadily over the years and has been essential to successful immunization. Virus variation affecting the surface antigens of the virus is seen as the principal obstacle to the application of vaccines in man. So significant are the changes occurring during antigenic drift that former concepts of a polyvalent vaccine cannot provide a solution of the problem of the composition of vaccines. Disrupted virus vaccines appear to provide the answer to the prevention of vaccine reactions.

Url:

DOI: 10.1136/pgmj.55.640.78

Affiliations:

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The search for the ideal influenza vaccine.

The search for the ideal influenza vaccine.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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